Did you ever wonder how highway designers number interstate highways? (Ok, so maybe I need to get out a little more.) The Department of Transportation has a writeup explaining that the madness to their method:
The Interstate route marker is a red, white, and blue shield, carrying the word "Interstate", the State name, and the route number. Officials of AASHTO developed the procedure for numbering the routes. Major Interstate routes are designated by one- or two-digit numbers. Routes with odd numbers run north and south, while even numbered run east and west. For north-south routes, the lowest numbers begin in the west, while the lowest numbered east-west routes are in the south. By this method, Interstate Route 5 (I-5) runs north-south along the west coast, while I-10 lies east-west along the southern border.
To prevent duplication within a State, a progression of prefixes is used for the three-digit numbers. For example, if I-80 runs through three cities in a State, circumferential routes around these cities would be numbered as I-280, I-480, and I-680. The same system would be used for spur routes into the three cities, with routes being numbered I-180, I-380, and I-580, respectively. This system is not carried across State lines. As a result, several cities in different States along I-80 may each have circumferential beltways numbered as I-280 or spur routes numbered as I-180.United States Department of Transportation